joulukuu 2020

JAK-inhibiittorit nivelreumassa

Biologisten sytokiinisignalointia estävien lääkkeiden teho nivelreumassa on vahvistanut sytokiinien vaikutusten eston varteenotettavaksi hoidoksi reumasairauksissa. Viime vuosikymmeninä sytokiinisignalointia estävien JAK-proteiinien aktiivisuutta inhiboivien pienmolekyylien kehitystyö on ollut aktiivista. Neljä JAK-inhibiittoria maailmanlaajuisesti on saanut hyväksynnän nivelreuman lääkehoitoon, ja useita muita on arvioitavana kliinisissä kokeissa.

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JAK-inhibiittorit nivelreumassa

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