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KRAS inhibitor sotorasib may become the new standard for advanced NSCLC with KRAS mutations

In the Phase II CodeBreak 100 study, sotorasib has shown clinically durable benefit with a favorable adverse event profile in patients with KRAS p.G12C mutations who have previously received up to 3 treatments for NSCLC. At ESMO 2020, sotorasib surprised in the phase I study and in his presentation at the WCLC 2020 Presidential Symposium, Dr Bob Li of Memorial Sloan Kettering Cancer Center presented positive phase II results.

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