Spatial Sub-Sister Cell Trajectories in High-Grade Serous Ovarian Cancer

Ada Junquera, Doctoral Researcher at the University of Helsinki, presents single-cell multiomic profiling of high-grade serous ovarian cancer revealing spatially segregated “sub-sister” cell trajectories associated with clinical outcomes. The study uses interval debulking surgery samples and spatial multiomic analysis to characterize tumor cell heterogeneity and adaptation after chemotherapy.